Tuesday, August 31, 2010

Natural 'Cures' for Cancer May be Nearly as Ineffective as Chemotherapy!

A recent article on the Stuff website entitled 'Research Shows Natural Cancer Cures Don't Cure' quotes a speech at Victoria University by Professor Shaun Holt in which he states that there are no complementary natural therapies that could cure cancer. 


He goes on to state that his findings are not his opinion but were based on years of scientific research...


This reminds me of the mainstream medical communities constant criticism of complementary and natural medicine as not being 'evidence based medicine', in spite of existing and emerging research, and when the evidence backing mainstream medicine is not always very convincing


I will say that I was not at the lecture, nor do I know Professor Holt, and so I am only basing this reply on what has been reported.


How effective are mainstream methods?
Mainstream methods for treating cancer involve invasive and destructive protocols including surgery, radiation therapy and chemotherapy.
These are considered in mainstream medicine to be the best options for treating cancer.


A recent extensive research review published in the Journal of Clinical Oncology found that the overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA.
The contribution to survival of this mainstream therapy is under 2.3% on average!


This study, undertaken by several respect oncologists, also over estimated chemotherapy effectiveness wherever data may have been uncertain. 


Relative Risk
Oncologists routinely express the benefits of chemotherapy in terms of 'relative risk'. 
Relative risk is a statistical means of expressing the reduction in risk - in relation to the rate of risk itself. Therefore if your risk of death from a condition was 5% before treatment and 2.5% after, the effectiveness of the treatment (in survival rate) would be 50%. When a 50% increase in survival is mentioned to patients it is easy to see what the likely decision for treatment will be. However the decision to undergo treatment might be quite different if the rate of improvement was given in absolute terms. 
One must also remember that physicians are often (inadvertently) misled by statistical sleight of hand. It is easy to understand the willingness of a physician to prescribe a treatment that offers a '50% improvement in survival rates..' 
In fact physicians are often more inclined to prescribe drugs (believing them more effective) when results of studies are expressed in relative rather than absolute terms (Bucher 1994) and physicians are more likely to recommend chemotherapy when presented with relative risk figures of effectiveness as compared to absolute risk statistics (Chao 2003).


We can see that the way that medical information is presented in the literature has a large role to play in whether a treatment will be a) recommended and b) uptaken by the patient (Note: 80% of patients choose what their oncologist recommends.)


In an example of how chemotherapy is oversold, the authors of the aforementioned study cite that in 1998 in Australia, out of the total of 10,661 women who were newly diagnosed with breast cancer, 4,638 women were considered eligible for chemotherapy. Of these 4,638 women, only 164 (3.5 percent) actually gained some survival benefit from chemotherapy. As the authors point out, the use of newer chemotherapy regimens including the taxanes and anthracyclines for breast cancer may raise survival by an estimated additional one percent — but this is achieved at the expense of an increased risk of cardiac toxicity and nerve damage.


Study End Points
The only statistic that really matters to cancer patients is long term survival. Secondary to that, but crucially important to is quality of life. 
Many studies set arbitrary (and often self serving) end points of the study that unfairly skew the results in favour of a curative effect. Highly toxic or highly invasive treatments that destroy cancerous cells, whilst wreaking havoc on the body will undoubtedly slow or remove tumorous activity in the short. But the effect on quality of life is huge, that rates of relapse are high, and underlying health factors that may have precipitated the disease are left to potentially reinstate the problem. 


The Placebo Effect
The placebo effect is often cited as a rationale for some of the improvements seen in natural therapies practice and research. 
However this point is moot for the following reasons:


Mainstream medicine is also largely based on the placebo affect
Drug therapy and even surgery have been conclusively demonstrated to be to a greater or lesser extent reliant upon the placebo effect for their effectiveness. 
Many drugs only slightly outperform placebo, and it is impossible to know whether the additional benefit is always as a result of the drug itself or because of an enhanced placebo effect due to side effects (if you feel an effect in the body - even if negative, you are more likely to 'believe' that it is working.)


The placebo effect by any other name is 'self healing'
The placebo effect is really an example of our ability to self heal. It shows that our beliefs drastically affect our physiology and indicates just how much power we have to positively affect our health status. 
The collective belief that we have in the 'healing' power of modern medicine and the physicians that prescribe to it's principles is sure to affect the efficacy of treatment. And this is not necessarily negative! If anyone is helping people to be healthier and to not be stricken by illness then that is a huge positive. But to use the placebo effect to deride, universally a whole paradigm of medicine whilst utilising it's effect to solidify your own is naive at best. 


Spontaneous Remission
There are countless examples of spontaneous remission from cancer sometimes from serious/terminal forms.


These are generally discounted by the mainstream medical community as aberrations, and unlikely ones at that. But the rate of spontaneous remission in breast cancer for example may be as high as 22% (Zahl et al. 2008). These same researchers had previously performed research in Norway comparing breast-screened and non breast-screened populations, showing that breast cancers can remit spontaneously. (Therefore although not denying the value in breast screening there are cases where women do not realise they have cancer and it resolves itself without intervention.) 


A tantalising question arises for me when reading research like this ~ How many of us have had (and recovered from) cancer without even realising it?


The incidence of 'spontaneous remission' (perhaps a misnomer?) is related to many, many lifestyle and other factors. For example if someone decides to change their nutritional habits, exercise and reduce stress (all factors in the development of cancer) their likelihood of remission/regression should increase. However this may still  be included as a 'spontaneous' remission. It is also poignant to note the nutrition and lifestyle interventions are at the core of complementary medicine. 


If nothing else spontaneous remission throws an indictment over the practice of negative reinforcement still in practice. "You have 3 months to live" can become a self fulfilling prophecy (and there are several examples in the medical literature of cases where someone given a certain amount of time to live was subsequently found - post mortem - to have not actually had the 'terminal' illness.)


I have been told that to tell a patient that they might survive is giving them 'false hope' but that very 'false hope' could potentially turn into the 'belief' that the placebo effect has shown to be so powerful in potentially improving one's outlook and health. It could also be the trigger to make the lifestyle changes needed to improve and recover one's health. 


Picking and Choosing
In the Stuff article, Professor Holt mentions some of the alternative methods that do have validity in his opinion. He includes acupuncture, aromatherapy, massage and art therapy as modalities that can reduce 'symptoms' of cancer. He seems to be picking and choosing... 
He calls Reiki 'chanting mumbo-jumbo', in spite of the many studies showing reduction in pain, anxiety and other symptoms of both cancer and it's treatments from Reiki and other hands on healing modalities (Pohl et al 2007). For example one of the major contributing factors to reduced quality of life and a factor that influences recovery in cancer is fatigue. Fatigue may be reduced by Reiki treatments more than just rest (Tsang et al 2008).
 (Side note: As a master Reiki practitioner and intuitive energy worker I certainly don't chant when doing energy work!) So shouldn't Reiki and other treatments that give benefit be put in the category with the above rather than derided? 
Hands on energy healing has shown a high rate of effectiveness in encouraging small tumour remission in mice (Bengston & Krinsley 2000) and there is emerging research the various 'bio-energy' healing modalities may be efficacious for encouraging the remission of tumours. 


Research on distance healing is lacking but of the very small amount of studies done several show discernible improvements in health. A double blind study on AIDS patients showed that those undergoing distance healing (without their knowledge) had lower incidence of AIDS defined illness, less severity of symptoms, fewer doctors visits and fewer hospitalisations. 
(That being the case what is the harm! Energy healing modalities are safe, can be used in conjunction with other modalities and evidence suggests they may be extremely effective.)
I would say that mainstream medicine treats symptoms of being. Where lifestyle, genetics, actions and beliefs provide the mulitifactorial basis for dis-ease a set of symptoms will proliferate. 


Sometimes it may be necessary to utilise drugs and surgery to save lives and improve quality of life - and I am all for this. But the wholesale use of solely mainstream medicine without recognising the benefits of complementary modalities for prevention, support...and curative treatment of many illnesses is cavalier and irresponsible. 



Nobody Cures, Nobody Heals
No one 'cures' anybody else, and the term 'healer' is simply an easy description at times for people that help and facilitate a 'process of healing' (but one I am loathe to use.) 
In reality anyone has inordinate power within themselves to avoid illness, to recover from illness and to lead a happier, healthier life. 
Illness must be recognised for what it is - a symptom profile that has arisen dependent upon many factors. Because of the multifaceted nature of illness a multifaceted (ergo 'holistic') approach to treatment should be undertaken, and this requires utilising the resources available to us. There are pragmatic integrative practitioners in both mainstream and alternative medicine and we should consult with experts that will give us the best outcome for our health. 
It is hilarious to me to read in the conclusions of studies that show the efficacy of herbs that people should consult a 'medical doctor knowledgeable in the use of herbs'! While there may be doctors who are...there is also a whole profession (medical herbalism and naturopathic medicine) where that is exactly what we do! Would you consult your herbalist for information on how to best perform brain surgery?


In some respects I agree with Professor Holt, in that nothing, including both mainstream medicine and CAM, really 'cures'. 
It is the individual who co-creates their future reality in the now and provides the impetus for healing and recovery. 


About Cliff


Cliff Harvey is a Naturopath specialising in holistic nutrition and mind-body-spirit medicine. He has lectured at prestigious universities, colleges and industry conventions and his articles have been published in magazines around the world. He is the owner of Katoa Health Clinic (www.katoahealth.com) and is the author of 'Choosing You! How you can choose to live the life of your dreams.' Find out more about Cliff at www.cliffharvey.com

12 comments:

  1. Anonymous9:04 AM

    To say medicine is largely based on placebo is horse-crap. Drugs need to be tested thoroughly in double-blind tests precisely to eliminate any placebo effect.

    The author seems to be affected by Dunning-Kreuger effect (wikipedia link) with regards to science and medicine. To suggest people disregard real medicine and use their non-proven brand of "psi healing" is dangerous and fraudulent. I sincerely hope cancer patients stick with real medicine for their own health.

    BTW, I think you meant to use "prestigious universities", as prestiges is not a word.

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  2. Thanks for your comment.
    I disagree with you obviously and that is fine, I do appreciate you taking the time to comment
    I will reiterate a couple of points though.

    - I did not say that all medicine is based on the placebo effect, nor did I say that it solely based on it. The fact remains though that there is conclusive evidence that drugs and surgery do rely on the placebo effect to some degree (based upon the particular drug or surgery).

    - As for suffering from the Dunning-Kruger effect....
    While I have my opinions (as you obviously do) I do like to think that my opinion is based on both research and experience and I realise fully that there are many, many experts in the field who may differ in their opinion from mine. Free and open debate is healthy, and necessary for people to make informed decisions.

    I don't think that people should reject mainstream medicine - simply that they know the risks, side effects and what can realistically be expected. To deride natural treatments as useless is just as dangerous in the long term as many lifestyle interventions (and yes in my opinion psycho-emotional and energetic interventions) can help to treat the underlying causes of illnesses rather than simply treating the symptom profile of an illness.

    I sincerely hope that cancer patients evaluate their options wisely, taking into account a realistic measure of the real risks and rewards of treatment and use ALL tools available to recover their health and wellness.

    Thanks for the spell check too...
    BTW - I think you meant 'Kruger' as 'Justin Kreuger' is a different guy altogether! :)

    Thanks again for taking the time to read and comment on my blog post.
    ~ Cliff

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  3. http://www.wired.com/medtech/drugs/magazine/17-09/ff_placebo_effect?currentPage=all
    ~great article on more info regarding the Placebo effect.
    The 'Placebo effect' shows the power we have as humans to self heal. :) Stay open to the infinite possibilities of life, and a new world will open for you!

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  4. Also for more information, I highly recommend anyone to read Dr. Bruce Lipton "The Biology of Belief: Unleashing the Power of Consciousness, Matter, & Miracles"

    The Biology and Belief is loaded with clinically proven cases in which belief played the critical part in healing (or death):

    Knee arthritis patients who received fake surgery recovered just as well as patients who received real surgery. (Both groups received the same post-operation care, including exercise.) They believed they received real treatment, and that was enough to throw away their canes and play basketball with their grandchildren.

    In depth analysis of FDA data shows antidepressant pills did not outperform the sugar pills. The reason the depression patients got better was because they believed the pill would help. (Don’t ask me why then those pills got approved by FDA.)

    A case of a cancer patient who died some time after the initial treatment, as expected with this type of cancer. However, the autopsy revealed he didn’t die of cancer — meaning he died because he, along with the doctors, believed he would die.

    Belief is very this powerful!
    "What Ever The Mind Can Conceive and BELIEVE,
    It Can Achieve." -Napoleon Hill

    -Melissa Lawrence C.H.
    Hypnotherapist, Advanced Psych-K practitioner, Soul Coach and Wellness Guide. With a background in Spiritual Alchemy, Energy Medicine, Energy Psychology & Healing.

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  5. Thanks Melissa! Loads of examples of medicines not outperforming placebo. I did a tonne of research on depression at college and I was staggered by the lack of verifiable evidence for anti-depressant drugs and the theories that are taken as gospel by the medical community at large when the evidence is lacking in the extreme. I'm all for 'evidence based medicine' so let's see some evidence...and not ignore evidence of the benefits of many treatments that are considered 'alternative'. Most of my treatment protocols are based, at least initially on nutritional interventions and lifestyle (exercise and stress reduction) which Doctors often ignore, in spite of a HUGE compendium of research and knowledge showing the benefit. But then again I wouldn't expect them to. Docs are experts in pharmacology and surgery and for that we must be thankful as these can save our lives and improve our quality of life (I may well be dead were it not for the medical intervention in the early stages of my battle with Crohn's) but these interventions are not the only ones!...and often not the best option. Let's just all learn to reconise our skills and limitations and get on with the important job of helping people to be happier and healthier! :)
    ~ Cliff

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  6. Seems to me that the Anonymous commenter made a judgment on one particular part of your post. He/She didn't notice that you were NOT in fact telling people to ignore medicine but instead look at integrating and opening the heart to other parts of our Self.

    And in fact, the placebo is an integral part of medicine. I won't go into reasons for and against, and will say that the greatest learning comes from being curious and staying in the wonder of all things scientific and spiritual (and more!).

    Cheers to you, Cliff, for offering the world yet another possible side of the coin. Keep up the great writing!!!

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  7. Stress reduction in the face of a capitalist division of labor means that only a few can benefit from stress reduction therapies.

    Perhaps the belief helped, and the stress free basketball playing with grandchildren also helped afford the recovery time necessary to re-energize patients of placebo and real surgeries.

    If you think you have to be back at 5am on the assembly line, because your mom kept you inside as a child with a box of fruit loops and sat you in-front of the TV while she smoked in the bathroom, and your options never developed fully, you would fear losing your job.

    Hands up whose parents here are rich?

    My point?

    It's not the beliefs solely, but the differential and unequal access to energy, resources, skills, time, and knowledge that shapes beliefs from an early age.

    Beliefs evolve in a co-relation with technological development and the growth of abundance.

    While it may be possible for a few to heal themselves and live their dreams now, it won't be possible for all until full jouliarity exists by about 2040.

    Solar power and renewables are moving at an exponential pace, by 2012/2013 solar is on target to be the cheapest form of retail electricity.

    By 2020 it's possible that half of the planet will be powered by solar, wind, desalination, batteries, hydrogen, molten salts, thermal solar, thin film solar, LED lighting (25% of electricity consumption down by 2020 alone from LED's)

    Maslow postulated that in order for a human being to self actualize, that they first need to fulfill a hierarchy of other needs.

    By 2040, post humans have a good chance of reaching the thresholds necessary to move the entire planet into the information age, allowing us to change programming via the codes to life through molecular manufacturing processes on the nano scale.

    Not first without the coming crisis.

    Which brings me to depression.

    Guerrillas in the Mist:

    Researchers noticed within a group of apes, some which looked depressed, and others that looked happy swinging through the trees. They tried an experiment. They removed all of the depressed looking apes.

    They went back a year later.

    All of them were dead.

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  8. Anonymous12:46 PM

    No mainstream medicine works by the placebo effect. I ask that you provide me examples if you know of any. I'm talking about MAINSTREAM medicine. Also, open debate really has no bearing on effectiveness of treatments. It's either proven or it's not.

    Which brings me to the major problems with alternative medicine.

    1) The definition dilemma; Once any treatment is shown beyond doubt to be effective, it ceases to be ‘alternative’ and becomes just like any other part of medical knowledge. That means that alternative medicine’ must consist entirely of unproven treatments.

    2) The lying dilemma; if a treatment relies on placebo and is effective, it would be best to maximize the placebo. To do this, you have to lie to the patient about what is happening, ie give them a fake sugar pill, or fake surgery, or say its all due to psi-energy, chakras or miasms or whatever nonsense you want to make up to make them feel better. To maximise the effect you need to lie to the patient as often as possible.

    3) The training dilemma; who is going to train the people who offer alternative treatments? No credible university would touch this as essentially they have to make up as much nonsense as possible.

    Unfortunately for alternative medical "practitioners", they are trying to be truthful about their methods. This makes it easy to separate the quacks from the doctors.

    BTW, positive attitude is good, but it ain't going to cure heart disease or any other pathological illness. Thats pure delusion I am sorry.

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  9. I would beg to differ re: the placebo effect.
    There are numerous example of placebo being as effective as drugs, or nearly so.
    This IS true of some surgeries also. A 2002 study published in the New England Journal of Medicine (http://www.nejm.org/doi/pdf/10.1056/NEJMoa013259)showed that patients undergoing arthroscopic knee surgery improved at the same rate and had reduction in symptoms to the same degree as the placebo group.
    One could conclude that the surgery therefore is ineffective, but if that were the whole story then there would not be improvement in function for the patient. Because the surgery AND the placebo were both effective we can only conclude that the positive effect of the surgery were due to the placebo effect...therefore if the placebo effect is that powerful I would reiterate that belief has a huge role to play in healing.
    A recent review suggests that based upon this and other evidence that there is 'no benefit' to this type of arthroscopic knee surgery (abstract here: http://www.ncbi.nlm.nih.gov/pubmed/20839687)

    It is not so much about wishful 'positive thinking' it is about having the underlying and core beliefs that what we are doing will be effective in promoting our health.

    The effect of our underlying patterning and conditioning are now well recognised and verified. The field of Psychoneuroimmunology has shown us that we can be conditioned into allergies and adverse health responses by stimuli and that these can also be changed. I have seen this myself in practice, having helped several people to free themselves of allergies.
    These are verifiable and testable results.

    In practice, I and many other complementary health care providers base our instruction and treatment around the idea that the patient holds a large amount of 'power' within their own grasp for healing. This separates us from the 'healing dilemma' and is more forthright than claiming certain drugs and surgeries are going to help someone when in fact they do not work better than placebo.

    Now I am not suggesting in the slightest that ALL drug and surgery effect is due to the placebo effect! In fact in a lot of cases the placebo driven effect is very low. BUT if we can encourage self healing without surgery or drugs that have serious side effects in my humble opinion that is erring on the side of caution.

    Positive attitude alone is not the whole story. It is very important to recovery and if we look at it in a less one dimensional way we can see that the implications for health are innumerable. Stress is one of the key factors in the onset and perpetuation of many illnesses. Would one say that so called 'alternative' methods are ineffective for treating stress?

    Conditioned belief patterns are a major part of the internalised stress picture and therefore dealing with this has a huge role to play in treating illness.

    Mainstream medicine probably saved my life, but natural, wholesome living and so called 'alternative' methods allowed me to LIVE a vibrant and healthful life free from the effects of Crohn's disease (without the use of drugs). These same methods have helped my clients around the world to live healthier and happier.

    I hope to not come across as a zealot, but as a pragmatist. The only thing I decry is the wanton rejection of natural medicine, and more importantly the rejection of inordinate power of self healing that we all hold.

    Thanks again for your comments. They are appreciated.

    ~ Cliff

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  10. Anonymous11:58 AM

    In your original post you said "Mainstream medicine is also largely based on the placebo affect". Which is completely false, hence why I mentioned Dunning-Kruger. You have yet to back these claims up with any evidence, and you seem to misunderstand that placebo has no place whatsoever in mainstream medicine. The study you linked to basically showed that surgery was useless, as it had no difference between it and placebo. Would you use placebo if you needed an appendicectomy?

    Wholesome living, eating right, exercising etc is all part of a healthy lifestyle. It aint "natural" medicine. Keep in mind many poisons are "natural" so that word doesn't mean much.

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  11. How can you say it's false?
    In the study I mentioned there was a benefit from both placebo and surgery. I would agree that in this instance the surgery is ineffective, but the placebo is obviously effective, ergo the surgery (the most common intervention for this type of knee condition) is acting solely as a placebo. Which was my point - that many mainstream medical interventions rely at least on part and in this case in whole on the placebo effect. We just need to be cautious that when we see a benefit from drugs and surgery that we look deeper into why it has occurred and not put people through undue risk of complications and side effects.
    I don't mean to deride mainstream medicine, and I hope that my post hasn't come across that way. But I will stick to my guns regarding the placebo effect being evident in ANY healing modality and that often medical intervention isn't the best long term treatment course for many illnesses if it doesn't address fundamental underlying causes.
    You are right that natural means (herbal medicine etc) can also be dangerous.
    It seems we have an impasse. I appreciate your comments and taking the time to post.
    I think at the end of the day we are all on the same side, looking for viable healing results.
    I believe that the benefits of both mainstream and alternative medicine should be recognised based upon the evidence available, and I have see ample evidence both in experience and research that points to the viability of many CAM modalities.

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  12. Anonymous11:40 AM

    The study you point to confirms that arthroscopic surgery for the knee is not a proven treatment for arthritis, as it has no statistical difference between it and placebo. Placebo is entirely the domain of alternative therapies, as it involves deception of the patient.

    The only time placebo really works is with pain relief and other subjective outcomes. But seeing as you seem stuck to your guns that medicine DOES rely on placebo, I again ask that you provide evidence of this. You said ANY healing relies on it, so perhaps start with how an appendectomy relies on placebo. Or how anti-bacterial medicine cures athletes foot by placebo.

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